Automated synthesis of phosphorussulfur analogs of nucleic acids25 years on: potential therapeutic agents and proven utility in biotechnology
Identifieur interne : 002664 ( Main/Exploration ); précédent : 002663; suivant : 002665Automated synthesis of phosphorussulfur analogs of nucleic acids25 years on: potential therapeutic agents and proven utility in biotechnology
Auteurs : Gerald Zon [États-Unis]Source :
- New Journal of Chemistry [ 1144-0546 ] ; 2010.
English descriptors
- Teeft :
- Acad, Acid drug, Alphabetical order, American chemical society, Annual number, Antisense, Antisense agents, Antisense compounds, Antisense strand, Appl, Avid binding, Blood cancers, Brief survey, Centre, Chem, Chemical structures, Cleavage, Clinical development, Clinical trials, Clinical utility, Elemental sulfur, Exonuclease activity, Further detail, Genetic variants, Genome, Genomes project, Global distribution, Human genome, Initial commercialization, Isis, Isis pharmaceuticals, Journal publications, Large number, Lett, Life technologies, Ligation, Ligation cycles, Linkage, Molecular beacons, Mrna, Natl, Normal dntps, Nucleic, Nucleic acids, Nucleic acids symp, Nucleic years, Numerous investigations, Odns, Oligonucleotides, Patent publications, Pharmaceutical, Phosphorothioate, Phosphorothiolate, Phosphorothiolate linkages, Polymerase, Present account, Primer, Proc, Pubmed, Recherche, Ribonucleotide reductase, Royal society, Scifinder, September, Sequencing, Sirna, Solid probes, Stec, Such compounds, Sulfur, Tetrahedron lett, Therapeutics, Uorescently, Vivo imaging, Whole genome, Widespread interest.
Abstract
Replacement of non-bridging oxygen by sulfur in one or more internucleotide linkages in synthetic oligodeoxynucleotides (ODNs) was first fully automated in 1984. The present account highlights how ready access to these nuclease-resistant, phosphorothioate-modified oligodeoxynucleotides (PS-ODNs) and chemically related compounds, notably phosphorothiolates, has enabled remarkably broad advances across basic science, medical research, and biotechnology. These developments exemplify how an initially narrow-scope chemical reactionin this case, automated sulfurization of an internucleoside phosphitecan give rise to diverse applications far beyond initial expectations.
Url:
DOI: 10.1039/b9nj00577c
Affiliations:
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The present account highlights how ready access to these nuclease-resistant, phosphorothioate-modified oligodeoxynucleotides (PS-ODNs) and chemically related compounds, notably phosphorothiolates, has enabled remarkably broad advances across basic science, medical research, and biotechnology. These developments exemplify how an initially narrow-scope chemical reactionin this case, automated sulfurization of an internucleoside phosphitecan give rise to diverse applications far beyond initial expectations.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Zon, Gerald" sort="Zon, Gerald" uniqKey="Zon G" first="Gerald" last="Zon">Gerald Zon</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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